align windows between vertical and horizontal monitors?

One monitor is vertical for reading documents, the other horizontal. Dell monitors one is a p2422h, the other u2722d. It would be nice to have windows that span both monitors occasionally, but they get so misaligned as to make this untenable. Is there any easy way to get resolution settings and alignment in this configuration to allow distortionless spanning windows or am I just entering a world of hurt trying to do this?