If the Andromeda galaxy were made of antimatter, would we know? What about more distant objects?

My understanding is that "what happened to the antimatter?" is a bit of an open question. How sure are we that all of the matter we can see is in fact matter, and not antimatter?

Antimatter has the same mass, electromagnetic spectra, falls down, etc. Do we have a way of determining which version of matter distant objects are made of?